This systematic review investigates the evolving landscape of women and youth entrepreneurship in digital spaces between 2015 and 2026. With rapid digital transformation, marginalized groups increasingly leverage e-commerce, social media, fintech, gig platforms, and mobile technologies to launch and scale innovative ventures. The review synthesizes 57 studies, of which 22 high-quality papers were analyzed in depth, highlighting opportunities such as increased market access, financial inclusion, flexible business models, and enhanced visibility through digital communities. However, significant barriers persist, including digital literacy gaps, limited access to digital finance, socio-cultural restrictions, infrastructural challenges, and cybersecurity risks. Findings reveal that the pandemic accelerated digital adoption, strengthening entrepreneurial resilience but widening digital inequalities. The review concludes by identifying research gaps related to emerging technologies, rural participation, and sustainability of digital microbusinesses, and proposes future research directions to strengthen inclusive digital ecosystems