This study presents a structured multi-criteria evaluation framework using the Analytic Hierarchy Process (AHP) to identify and prioritize the key drivers influencing e-commerce growth in complex business environments. The framework focuses on five critical dimensions: technological advancement, market responsiveness, environmental sustainability, strategic alignment, and economic viability. AHP is employed to conduct pairwise comparisons and derive weights for each criterion and its sub-components, allowing a quantitative assessment based on expert judgments. The analysis reveals that technological drivers—such as digital infrastructure, automation, and AI—play the most pivotal role in enhancing operational efficiency and customer engagement. Environmental sustainability emerges as a growing priority, with green logistics and eco-conscious practices becoming essential for consumer trust and regulatory compliance. Market responsiveness, driven by personalization, omnichannel strategies, and shifting customer preferences, demands agility and innovation. Strategic alignment ensures that e-commerce initiatives are guided by long-term vision and adaptability, while economic viability underscores the importance of financial sustainability. The hierarchical structure of the framework enables organizations to break down complex decision-making into manageable components, facilitating targeted resource allocation. By integrating AHP, this research offers a transparent, evidence-based approach that supports balanced and forward-looking strategic planning in the e-commerce sector. The findings emphasize that sustainable growth depends on harmonizing multiple drivers rather than focusing on a single aspect. Ultimately, the framework serves as a practical tool for practitioners and contributes to scholarly understanding of digital commerce dynamics, equipping stakeholders to navigate a rapidly evolving and competitive global marketplace with strategic clarity.