Engaging in regular physical activity and exercise has many physical and psychological health benefits; however, performing exercises without sufficient knowledge of safety guidelines may lead to poor training methods, overload, potential injury, and unsafe exercises. University students are becoming increasingly aware of exercises through their peers, social media platforms, fitness apps, and other non-formal sources. Students' misconception on exercise intensity, warm-up, recovery process, pain, and fluid intake may affect their approach to training; nevertheless, exercise knowledge, exercise beliefs, and actual physical fitness of participants have not been investigated simultaneously yet. This conceptual paper suggests a framework of connections between awareness of exercise safety and exercise misconceptions on four health and physical fitness indicators: resting heart rate, resting blood pressure, handgrip strength, and sit-and-reach flexibility. A narrative synthesis based on theory has been used to develop the suggested framework that has generated three propositions regarding the relationships among awareness, misconceptions, participant characteristics, and selected indicators. Further, a cross-sectional research design will be used to test the framework, consisting of a questionnaire and Sports Science Laboratory tests at different university. The paper presents an example of a research-based approach to exercise-safety education in the universities as well as demonstrates how the University Sports Science Laboratory can be used for this purpose. This project was funded by Seed Money of Poornima University.