Artificial intelligence (AI) and personalized technologies have propelled the quick development of E-Commerce 5.0, which has revolutionized online buying by providing tailored promotions, predictive search, and product suggestions.  Concerns regarding security, privacy, and customer trust are raised by these advances, even while they improve convenience and engagement.  This study examines consumer perceptions of security and confidence in Thoothukudi district AI-powered e-commerce platforms. A systematic questionnaire measuring demographics, platform usage, and opinions of trust and security on a 5-point Likert scale was used to gather primary data from 130 respondents.  Descriptive statistics, frequency distributions, ANOVA, and independent t-tests were used in the investigation to look at the connections between trust perception and demographic characteristics. The results show that most respondents believe AI-powered e-commerce platforms are safe and reliable, and they have faith in payment gateways, data security protocols, privacy guidelines, and the ethical application of AI.  Furthermore, perceptions of security and trust are largely unaffected by demographic variables like age and gender, suggesting uniform confidence among all user groups.  The study provides useful insights for e-commerce providers in semi-urban and urban markets like Thoothukudi by highlighting the significance of transparent security measures, clear communication regarding privacy and refunds, and responsible AI practices in fostering customer trust, satisfaction, and continued usage..