Polycystic ovary syndrome is a multifactorial endocrine disorder characterized by hyperandrogenism, metabolic dysregulation, and systemic manifestations extending beyond reproductive dysfunction. This prospective experimental study aimed to evaluate the clinicobiochemical and metabolic associations of polycystic ovary syndrome with dermatological manifestations and renal function alterations among reproductive-age women. Quantitative assessment demonstrated that patients with polycystic ovary syndrome exhibited significantly higher serum testosterone (2.1±0.6 vs 0.9±0.3 ng/mL, p<0.001), insulin resistance indices (HOMA-IR 3.8±1.2 vs 1.9±0.8, p<0.001), and reduced estimated glomerular filtration rate (89±12 vs 102±10 mL/min/1.73m², p=0.002). Dermatological manifestations including hirsutism, acne, and acanthosis nigricans showed strong correlation with hyperandrogenism and metabolic indices (p<0.001). Multivariate analysis identified insulin resistance and serum testosterone as independent predictors of both cutaneous severity and renal function decline. These findings establish a novel clinicobiochemical link between dermatological manifestations and early renal alterations in polycystic ovary syndrome, suggesting that skin changes may serve as early indicators of systemic metabolic dysfunction. The study highlights the importance of integrated clinical, biochemical, and imaging assessment in improving early diagnosis and preventing long-term,complications
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