Advances in Consumer Research
Issue:6 : 3152-3155
Original Article
Association of Serum Lipid Profile Changes and Maternal Biochemical Profiling With Pregnancy-Induced Hypertension: Evaluating the Role of Maternal Nutrition and Cardiovascular Risk
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1
Cardiologist, NMC Royal Hospital, Dubai, UAE.
2
Specialist Obstetrics and Gynecology, SGH, Dubai, UAE.
3
Assistant Professor, Biochemistry, NUST School of Health Sciences, National University of Sciences and Technology, Islamabad, Pakistan.
4
Assistant Professor, Biochemistry, M. Islam Medical and Dental College, Pakistan
Abstract

Pregnancy-induced hypertension is a major obstetric complication contributing significantly to maternal and perinatal morbidity and mortality worldwide. Emerging evidence suggests that dyslipidemia, altered maternal biochemical profile, and poor nutritional status play a central role in endothelial dysfunction and abnormal placentation, ultimately leading to hypertensive disorders of pregnancy. The present study aimed to evaluate the association of serum lipid profile changes and maternal biochemical parameters with pregnancy-induced hypertension and to assess the role of maternal nutrition in cardiovascular risk stratification. A prospective analytical study was conducted on 292 pregnant women between 18 and 40 years of age, enrolled between January 2025. Serum lipid profile, liver and renal function tests, fasting glucose, and nutritional status indices were assessed and compared between normotensive and pregnancy-induced hypertension groups. Women with pregnancy-induced hypertension demonstrated significantly elevated serum total cholesterol, triglycerides, low-density lipoprotein levels, and reduced high-density lipoprotein levels (p<0.001). Abnormal biochemical markers including elevated uric acid, alanine aminotransferase, and creatinine were also significantly associated with hypertensive pregnancy outcomes. Poor maternal nutritional status, low protein intake, and higher body mass index were independently associated with adverse lipid and biochemical alterations. Multivariate regression analysis identified dyslipidemia, elevated uric acid, and poor nutritional status as strong predictors of pregnancy-induced hypertension. The study highlights the importance of early biochemical screening and nutritional assessment in antenatal care for prevention and early identification of hypertensive disorders in pregnancy..

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