Telepharmacy, defined as the provision of pharmaceutical care through telecommunications and digital technologies, has emerged as a transformative component of modern healthcare systems. In India, telepharmacy has expanded rapidly due to increased internet penetration, digital health initiatives, and the need to improve access to medicines in rural and underserved areas. However, regulatory development has not kept pace with technological advancement. This review critically examines the existing legal framework governing telepharmacy in India, including the Drugs and Cosmetics Act, 1940, Drugs and Cosmetics Rules, 1945, Information Technology Act, 2000, and Telemedicine Practice Guidelines, 2020. The paper identifies key regulatory gaps such as absence of telepharmacy-specific legislation, inconsistent state implementation, lack of standardized e-prescription norms, data privacy concerns, and unclear professional liability standards. Comparative analysis of regulatory frameworks in the United States, Australia, and Canada highlights global best practices in licensing, quality assurance, digital integration, and patient privacy protection. The review concludes with policy recommendations aimed at strengthening telepharmacy governance in India to ensure equitable, safe, and accountable healthcare delivery...