Workplace ostracism (WOS) significantly impacts employees’ job performance (IWP). This study examines the mediating role of perceived organizational support (POS) and the moderating role of personality inventory (PI) in the context of the Indian information technology (IT) sector. Data were gathered from 369 IT professionals in southern India using a structured survey with established measurement scales. The pyPLS Python library facilitated Partial Least Squares Structural Equation Modeling (PLS-SEM), allowing an in-depth analysis of the hypothesized relationships, including mediation and moderation effects. However, the effect size is negligible, and its practical significance warrants careful consideration. Managerial interventions such as promoting inclusive work cultures and resilience-building programs can help sustain employee outcomes despite adverse interpersonal dynamics. This research contributes to workplace ostracism literature by elucidating the roles of perceived organizational support and personality in determining job performance. It provides new insights into these dynamics in the IT sector, ensuring methodological robustness through PLS-SEM analysis and visualization.