In an increasingly competitive marketplace, product quality has become a vital differentiator for organizations striving to meet evolving customer expectations. This paper examines the impact of three prominent quality management methodologies—Six Sigma, Total Quality Management (TQM), and Lean Manufacturing—on product quality, utilizing a Structural Equation Modelling (SEM) approach. Drawing on a sample of 257 professionals with experience in quality management, the study investigates how these methodologies contribute to enhancing product quality, particularly in the context of modern industries such as digital content marketing. The research highlights the distinct and combined effects of Six Sigma, TQM, and Lean Manufacturing on key product quality dimensions, including performance, reliability, and customer satisfaction. Six Sigma’s data-driven approach, TQM’s emphasis on continuous improvement and organizational culture, and Lean Manufacturing’s focus on waste reduction and process efficiency all demonstrate significant positive impacts on product quality. The study’s findings suggest that integrating these methodologies can amplify quality management outcomes, offering organizations a comprehensive strategy for operational excellence. The use of SEM provided robust insights into the interrelationships between these quality management techniques, underscoring their importance for sustaining competitive advantage in diverse sectors.