In the context of strong digital transformation in Vietnam, e-commerce is a crucial tool that helps promote economic development in rural areas, where there are many barriers to accessing markets, technology, and information. This study aims to examine the impact of e-commerce on the economic life of rural residents in the Red River Delta. Data was gathered through in-depth interviews with rural business households, local officials, and business representatives. The findings indicate that e-commerce not only helps increase income and expand markets for agricultural products but also shifts people's production mindset and business organization models. However, the study also highlights several challenges, such as limitations in digital infrastructure, operational capacity, and the lack of coordinated support policies. Based on these insights, the article suggests policy recommendations and solutions to foster the sustainable development of e-commerce in rural areas of the Red River Delta.