Supply chain modernization through automation in manufacturing and warehousing operations remains essential for securing the United States’ national interests and economic prosperity and global stabilityImplementing autonomous mobile robots (AMRs) equipped with AI forecasting, IoT sensors, and computerised retrieval and storage systems (AS/RS) improves the effectiveness of processes by 30-50%, reduces labour costs by 20-30%, and increases space utilisation by 40% in storage facilities. AI-based demand forecasting systems achieve 95% inventory correctness and RPA technologies operate at processing speed increases up to 60%. The innovative system implementations enable manufacturers to perform production just in time and maintain real-time monitoring and fast disaster response which strengthens both economic stability and grounds national security. The combination of domestic automation helps the nation decrease dependence on foreign supply chains and generates high-tech positions which contribute to future industrial strength. Smart sensors used with digital twins allow organizations to prevent maintenance issues prior to breakdowns thus minimizing downtime by 50%. U.S. economic growth alongside secure critical logistics depends on scalable automation investment and intelligent infrastructure development which will make the supply chain stronger as a strategic asset