The study investigates the effectiveness of the Indian Knowledge System (IKS) integration into the modern management practices in creating an impact on the efficiency of decision-making and strategic performance of an organization. The aim is to establish the association between IKS-based practices and decision efficiency research the influence of IKS principles on performance with the aid of regression analysis and explain essential IKS elements that may be applied in the modern management. A quantitative dominant and mixed-method research design was adopted and a sample of 200 respondents with varied academic and professional backgrounds was used. The data was gathered using structures surveys on the exposure to IKS, organizational practice and decision making indicators. The analysis of descriptive statistics, correlation and regression were conducted by use of SPSS. Findings reveal that there is a moderate and significant positive relationship between the practice integration and the decision-making efficiency of IKS (r =.374, p <.001) and regression analysis indicates that IKS principles can explain 15.9% of the variance in strategic performance (B =.399, p <.001). The results confirm that IKS can play a significant role in clarity of ethics, reasonable thought, and strategic sustainability. The study finds that IKS mixed with analytical management constructions help to boost leadership within an organization and performance in the long-term. Nevertheless, the study has drawbacks of self-reported information, a geographically local sample, and cross-sectional design. Longitudinal models, multi-industry comparison, and more elements of the IKS should be included in the future research to develop more detailed and empirically confirmed models of sustainable, values-based management.