E-commerce has revolutionized the retail landscape, making online shopping a ubiquitous aspect of modern life. The convenience, variety, and efficiency of e-commerce platforms have transformed consumer behaviour and global business operations. However, despite these advancements in technology and widespread adoption, accessibility barriers persist for many users, particularly those with disabilities. These barriers include challenges in navigation, incompatibility with assistive technologies, and inadequate compliance with accessibility standards, which collectively hinder equal access to online shopping experiences. As digital marketplaces continue to expand, the need for inclusive platforms that cater to diverse user groups has become increasingly pressing. This research investigates the state of accessible e-commerce, focusing on user-centered and inclusive design principles, human-computer interaction, and the role of assistive technology in enhancing online shopping experiences. Through a synthesis of recent studies, this paper identifies the persistent challenges faced by users with disabilities, highlights emerging solutions aimed at overcoming these obstacles, and proposes actionable recommendations for creating universally accessible online shopping platforms. By addressing these issues, e-commerce platforms can not only comply with ethical and legal standards but also tap into a broader market, fostering inclusivity and equity in the digital economy