Industry 5.0 is an inventive thought which tends to achieve tech-based growth along with well-being and happiness. Further, it means, Human development and Technological advancement go together. Adhered to tools and technologies of IR 4.0, the life on earth has been robotized, overlooking internal feelings of discontentment and negativity giving rise to IR 5.0. It is a Human centric industrialization which aims to better humans in terms of skills, knowledge, values and well-being, so that the technology can be best employed to serve the humanity. There is shifting of attention from economic value addition to enhancing the social well-being. The current paper emphasizes spiritual strength which can improves health, reduces unethical behavior, nurtures a manager’s performance, promotes qualitative leadership `and ensures organization sustainability. The Spiritual health can be improved by meditation, yoga, spending nature time, traveling and discovering one's hobbies. Meditation can be a good exercise to improve mood, sharpen memory, elate humans, develop skills, reverse severe diseases and ameliorate overall health. The paper depicts a framework suggesting spiritually intelligent humans can better justify the success of Industry 5.0.