Passions have a complex effect on knowledge management in e-learning, a subject that has recently received much attention. Therefore, the study aims to examines the influence of passions on knowledge management in e-learning and the mediating role of self-regulation. The data were collected from 325 university students. The variables were measured using the 5-Likert scales. PLS-SEM is used to analyses the data and path analysis is used to test a hypothesis. The study's findings show that passions have a significant and a positive relationship with knowledge management in e-learning and self-regulation. In the same way, self-regulation has a significant & positive relationship with knowledge management in e-learning. Correspondingly, mediation of self-regulation exists in between passions and knowledge management in e-learning. The study can promote the creation of customized e-learning strategies, encourage the development of self-control abilities, and solve issues related to distant learning, thus promoting a more stimulating and productive learning environment for students in Nepal. In e-learning, self-regulation will contribute to education quality because it promotes inclusive and lifelong learning.