Human Resource Information Systems at organizations have evolved to new paradigms and platforms over decades. Having different needs, size, operations and business, almost every contemporary organization has implemented HRIS for its human resource management. Some of the organizations have reaped phenomenal benefits by implementing HRIS and few are yet to realize the importance, while a reasonably good number of organizations have found it difficult to implement HRIS. An exploratory study has been conducted to discover the facilitating and inhibiting factors for the successful implementation of HRIS. Based on a sample of one hundred sixty-seven primary HRIS users at pan India level organization, exploratory factor analysis coupled with descriptive statistics, chi-square and Anova were applied to test the hypothesis and to further establish the factors leading to successful implementation of HRIS in organization. The findings of the study suggest that factors like the size of the organization, need of implementing HRIS, characteristics, impacts of HRIS on HR functions and processes, and problems that limit HRIS’ use, are the factors, which play facilitating and inhibiting roles to the success of HRIS. The study is expected to add to the existing academic framework of HRIS and will also leverage HR professionals in the effective planning, designing and implementation of HRIS at their organizations